The Brain Topography Associated with High versus Low Contextual Constraint in Dominant Temporal Lobe Resected Patients: Potential Reorganization of Lexical Access

Previously reported data involving healthy normals showed that under low constraint, low accuracy conditions the left inferior frontal gyrus, a structure important for semantic comprehension and lexical access, was significantly activated.2 In this project, we investigate whether a differential response to accuracy and contextual constraint is present in left hemisphere language dominant patients whose temporal lobe has been compromised by intractable epilepsy and subsequent anterior temporal lobectomy (ATL).