Risk factors for AD: relationship between task activation and resting state connectivity

Risk factors for AD: relationship between task activation and resting state connectivity

In a previous fMRI experiment using a low effort, high accuracy (>85% correct) semantic memory activation task involving the discrimination of famous from unfamiliar persons (Leveroni 2000), we found that MCI patients and cognitively intact older individuals at-risk for AD (family history + APOE...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:NeuroImage (Orlando, Fla.) Fla.), 2009-07, Vol.47, p.S91-S91
Hauptverfasser: Durgerian, S., Woodard, J.L., Seidenberg, M., Nielson, K.A., Antuono, P., Guidotti, L., Zhang, Q., Lancaster, M., Hantke, N., Butts, A., Rao, S.M.
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
Memory
Risk factors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In a previous fMRI experiment using a low effort, high accuracy (>85% correct) semantic memory activation task involving the discrimination of famous from unfamiliar persons (Leveroni 2000), we found that MCI patients and cognitively intact older individuals at-risk for AD (family history + APOE [epsilon]4 allele) exhibited hyperactivation in memory related circuits, including the posterior cingulate (PC) and bilateral hippocampus (HIPP) (Fig.1).
ISSN:1053-8119
1095-9572
DOI:10.1016/S1053-8119(09)70716-5