Caloric and Non-caloric Versions of a Soft Drink Differentially Affect Taste Activation

Conclusions The strongest effect of energy content was found in the amygdala, which was more activated by non-caloric orangeade than by caloric orangeade before, but not after treatment. [...]amygdala activation appears to reflect sensory satiation for the sweet taste of the non-caloric orangeade. [...]we found differential activation of brain areas implicated in food intake regulation by caloric and non-caloric versions of a soft drink. [...]our results show that sensory and metabolic satiation differentially affect taste activation.