1417 Metabolic Syndrome and Insulin Resistance in Children and Adolescents

Overweight and obesity in children and adolescents have become a major public health problem in recent years. The prevalence of metabolic syndrome in childhood increases in parallel with the high prevalence of obesity in children. The metabolic syndrome was defined as having at least three of the following: abdominal obesity, low high-density lipoprotein (HDL) cholesterol, hypertriglyceridemia, hypertension, and/or impaired glucose tolerance. Insulin resistance is the principal metabolic abnormality that is common to the development of the metabolic syndrome in children and adults. Metabolic syndrome was found in %17.2 (12 cases). In our study, we aimed to investigate the potential risk factors in development of obesity evaluate metabolic syndrome and ınsulin resistance frequency in children and adolescent population. Seventy obese children with a mean age of 10.8±2.47 years and body mass index > 95th percentile were enrolled the study. Patients were assesed birth weight, duration of breast-feeding, prevalence of obesity and typ 2 diabetes in parents, age at onset of obesity and components of metabolic syndrome. The diagnosis of metabolic syndrome were defined according to modified WHO criteria adapted for children. Each subject was submitted to an oral glucose tolerance test. Obesity and type 2 diabetes rates in parents of cases, were %42.8(30 cases) and %12.8 (9 cases) respectively. According to homeostasis model assessment insulin resistance (HOMA-IR) index, insulin resistance was determined %88.5 (66 cases). İn our study birth weight, duration of breast-feeding weren’t assosiation with metabolic syndrome and insulin resistance.