912 Incidence of Cytomegalovirus(CMV) Pneumonia Among Children Presenting with Severe Lower Respiratory Tract Infection at Dr George Mukhari Hospital

Background Pneumonia is a major cause of morbidity and mortality in under-five children with about 5million deaths annually in developing countries1. CMV is responsible for serious morbidity and mortality in immunodeficient children with pneumonia2. Objective To determine the incidence of CMV associated pneumonia in children with severe lower respiratory tract infection (LRTI). Methods Under-5year children with severe LRTI were enrolled over a 12months period. Severity criteria:accessory muscle use, supplemental oxygen, or assisted ventilation. Anthropometry and HIV status were recorded. Throat swabs were taken for CMV PCR and CMV serology was done. Consent and ethical approval obtained. Results 107children, aged 2weeks to 46 months (mean 5.96 mths) enrolled. Incidence of laboratory confirmed CMV was 40%(35/87); 67% among HIV-infected and 28% among HIV-uninfected (p