434 Relationship between Obesity and 8-Hydroxy 2- Deoxy Guanosine as an Oxidative Marker in Obese Adolescents of Giza

Background and Aim This study was conducted to assess the relationship between obesity markers (Body mass index “BMI”, fat percentage) and DNA oxidative marker 8-hydroxyl guanosine (OHG), as a predictor for future clinical problems in obese adolescents of Giza. Methods The study was conducted on 103...

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Veröffentlicht in:Archives of disease in childhood 2012-10, Vol.97 (Suppl 2), p.A127-A128
Hauptverfasser: Hameed, E Abdel, Wakkad, A El, Hassan, NEM, Sherif, L, El-Shaheed, A Abd, Sebii, H, Zayat, S El
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Sprache:eng
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Zusammenfassung:Background and Aim This study was conducted to assess the relationship between obesity markers (Body mass index “BMI”, fat percentage) and DNA oxidative marker 8-hydroxyl guanosine (OHG), as a predictor for future clinical problems in obese adolescents of Giza. Methods The study was conducted on 103 adolescents aged 13–18 years (22 boys, 81 girls). BMI was calculated as body weight (kg) divided by height (m2) squared and obesity was defined as BMI of 95 percentile. Fat percentage was determined by using Biological impedance technique. Oxidative stress markers as 8-hydroxyl guanosine, superoxide and gluthione were measured. The adolescents were divided according to BMI into two groups. Group I with BMI > 95 percentile and less than 97 percentile (obese) and Group ∩ with BMI > 97 percentile (severely obese). Results Significant differences were detected between the two groups of the study as regard obesity markers (BMI, fat %) and oxidative stress markers (lipid oxidation, superoxide dismutase enzyme activity, glutathione peroxidase enzyme activity, 8-hydroxyl guanosine) (p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2012-302724.0434