1293 Umbilical Artery Intima-Media and Wall Thickness in Infants of Diabetic Mothers and its Relation to Maternal Hyperglycemia

Background Children who are large for gestational age at birth and exposed to an intrauterine environment of either diabetes or maternal obesity are at increased risk of developing metabolic syndrome. This can be explained by exposure to high glucose and insulin levels in utero causing altered fetal adaptation and changes in normal fetal programming. Objectives The aim of the study was to evaluate preclinical atherosclerosis begins in utero. Methods We measured the umbilical artery wall thickness (ruWT) in the third trimester by obstetric ultrasound and umbilical artery intima media thickness (uIMT) in pathologic specimens of the umbilical cords obtained shortly after delivery and we investigated the relation between the these measurements and serum insulin, c-peptide level in cord blood and homeostasis model assessment of insulin resistance (HOMA-IR) in infants of diabetic mother (IDM). Study group divided into two groups as; large for gestational age (LGA)/IDM group, appropriate for gestational age (AGA)/IDM group and compared with control group. Results The LGA/IDM group had significantly higher insulin (p