GW27-e0379 Apelin attenuates aortic adventitial fibrosis in spontaneously hypertensive rats through modulating miR-1 and beta-catenin signaling

GW27-e0379 Apelin attenuates aortic adventitial fibrosis in spontaneously hypertensive rats through modulating miR-1 and beta-catenin signaling

Conclusions Our findings demonstrate beneficial effects of Apelin-13 on aortic oxidative stress, adventitial remodeling and fibrosis in hypertensive rats via modulation of the miR-1 and b-catenin signaling, thus suggesting potential therapeutic strategies by enhancing Apelin/APJ action for preventin...

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Veröffentlicht in:Journal of the American College of Cardiology 2016-10, Vol.68 (16), p.C15-C15
Hauptverfasser: Zhong, Jiuchang, Xu, Ran, Zhang, Zhenzhou, Xu, Yingle, Chen, Laijiang, Oudit, Gavin Y, Chang, Qing, Song, Bei, Gao, Pingjin
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Cardiovascular
Collagen
Hypertension
Internal Medicine
Rodents
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Zusammenfassung:Conclusions Our findings demonstrate beneficial effects of Apelin-13 on aortic oxidative stress, adventitial remodeling and fibrosis in hypertensive rats via modulation of the miR-1 and b-catenin signaling, thus suggesting potential therapeutic strategies by enhancing Apelin/APJ action for preventing hypertensive vascular remodeling and fibrosis.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2016.07.058