Novel approach to the design of potential bioactive alkaloid anabasine conjugates using click chemistry methodology

Anabasine‐containing azides and acetylenes were used as building blocks in copper(I)‐catalyzed 1,3‐dipolar cycloaddition reactions with a series of acetylenes and azides via click methodology to provide a range of anabasine conjugates being potential ligands for neuronal nicotinic acetylcholine rece...

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Veröffentlicht in:Heteroatom chemistry 2016-09, Vol.27 (5), p.245-252
Hauptverfasser: Artyushin, Oleg I., Vinogradova, Natalya M., Sharova, Elena V., Genkina, Galina K., Brel, Valery K.
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container_end_page 252
container_issue 5
container_start_page 245
container_title Heteroatom chemistry
container_volume 27
creator Artyushin, Oleg I.
Vinogradova, Natalya M.
Sharova, Elena V.
Genkina, Galina K.
Brel, Valery K.
description Anabasine‐containing azides and acetylenes were used as building blocks in copper(I)‐catalyzed 1,3‐dipolar cycloaddition reactions with a series of acetylenes and azides via click methodology to provide a range of anabasine conjugates being potential ligands for neuronal nicotinic acetylcholine receptors.
doi_str_mv 10.1002/hc.21322
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title Novel approach to the design of potential bioactive alkaloid anabasine conjugates using click chemistry methodology
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