Novel approach to the design of potential bioactive alkaloid anabasine conjugates using click chemistry methodology

Novel approach to the design of potential bioactive alkaloid anabasine conjugates using click chemistry methodology

Anabasine‐containing azides and acetylenes were used as building blocks in copper(I)‐catalyzed 1,3‐dipolar cycloaddition reactions with a series of acetylenes and azides via click methodology to provide a range of anabasine conjugates being potential ligands for neuronal nicotinic acetylcholine rece...

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Veröffentlicht in:Heteroatom chemistry 2016-09, Vol.27 (5), p.245-252
Hauptverfasser: Artyushin, Oleg I., Vinogradova, Natalya M., Sharova, Elena V., Genkina, Galina K., Brel, Valery K.
Format: Artikel
Sprache:eng
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Zusammenfassung:Anabasine‐containing azides and acetylenes were used as building blocks in copper(I)‐catalyzed 1,3‐dipolar cycloaddition reactions with a series of acetylenes and azides via click methodology to provide a range of anabasine conjugates being potential ligands for neuronal nicotinic acetylcholine receptors.
ISSN:1042-7163
1098-1071
DOI:10.1002/hc.21322