Synthesis, Photophysical, Electrochemical Studies, and Antioxidant Properties of Fluorescein-Linked Glycodendrimers

Fluorescein‐linked glycodendrimers 1, 2, 3, and 4 were synthesized up to the third generation with glucose surface groups and triazole as the bridging unit by using a CuI‐catalyzed click chemistry protocol. All the synthesized glycodendrimers showed comparable antioxidant behavior to that of the standard with ascorbic acid when tested with both the DPPH (1,1‐diphenyl‐2‐picryl hydrazyl) scavenging assay and HO radical scavenging assay methods. Higher generation glycodendrimers exhibited superior antioxidant activity than the lower generation glycodendrimers owing to the presence of a greater number of triazole units and multivalent glucose units. The fluorescence and UV absorption intensity increases with the increase in dendrimer generation. All the dendrimers 1–4 showed reduction peaks with negative potentials in their cyclic voltammograms. The next generation: Fluorescein‐conjugated glycodendrimers 1, 2, 3, and 4 were synthesized with a triazole bridging unit by using a CuI‐catalyzed click chemistry protocol. Higher generation dendrimers show better fluorescence emission, electrochemical properties, and antioxidant properties than those of the lower generation dendrimers.