Front Cover: Synthesis of a Fluorinated Sialophorin Hexasaccharide-Threonine Conjugate for Fmoc Solid-Phase Glycopeptide Synthesis (Eur. J. Org. Chem. 22/2016)

The cover picture shows in the background a snapshot of the beautiful landscape around Wallberg peak in the Mangfall mountain range near Munich (Bavarian Alps). It symbolizes the strenuous efforts required for the synthesis of complex carbohydrate‐based antigens and the journey towards the development of effective glycoconjugate vaccines. The first total synthesis of fluorinated hexasaccharide–threonine conjugates enables antigen mimics of sialophorin glycoprotein fragments to become accessible for biological studies and medicinal applications. Details of the synthetic strategy based on a [3+3']‐block glycosylation approach are discussed in the article by A. Hoffmann‐Röder et al. on p. 3709 ff.