Angiotensin-Converting Enzyme Inhibitor (ACEI)-Mediated Amelioration in Renal Fibrosis Involves Suppression of Mast Cell Degranulation

Background/Aims: The mechanism by which angiotensin-converting enzyme inhibitors (ACEIs) attenuate renal fibrosis has not been fully uncovered. Methods: Renal fibrosis in rats was triggered by unilateral ureteral obstruction (UUO) and treated with Enalapril. Results: Enalapril attenuated renal fibro...

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Veröffentlicht in:	Kidney & blood pressure research 2016-02, Vol.41 (1), p.108-118
Hauptverfasser:	Sun, Nan, Zhai, Lei, Li, Hui, Shi, Li-Hua, Yao, Zhi, Zhang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE inhibitors Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Cell Degranulation - drug effects Cell Degranulation - physiology Degranulation Drug therapy Exocytosis Fibrosis Health aspects Kidney diseases Kidney Diseases - drug therapy Kidney Diseases - pathology Male Mast cell Mast cells Mast Cells - drug effects Mast Cells - pathology Mice Original Paper Rats Rats, Sprague-Dawley Renal fibrosis
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Zusammenfassung:	Background/Aims: The mechanism by which angiotensin-converting enzyme inhibitors (ACEIs) attenuate renal fibrosis has not been fully uncovered. Methods: Renal fibrosis in rats was triggered by unilateral ureteral obstruction (UUO) and treated with Enalapril. Results: Enalapril attenuated renal fibrosis, as evidenced by the fibrosis scores (1.07±0.73 versus 2.18±0.75 for 200 mg/ml Enalapril versus control, p
ISSN:	1420-4096 1423-0143
DOI:	10.1159/000368549