ChemInform Abstract: 2‐Chloro‐4‐tetrafluorophenoxypyrimidine: A Versatile Reagent for C‐2 Prior to C‐4 Functionalizations

ChemInform Abstract: 2‐Chloro‐4‐tetrafluorophenoxypyrimidine: A Versatile Reagent for C‐2 Prior to C‐4 Functionalizations

2,4‐Substituted pyrimidines are prepared by C‐2 functionalization of 2‐chloro‐4‐tetrafluorophenoxypyrimidine (I) by cross‐coupling reactions followed by SNAr displacement at C‐4 position with a variety of amines.

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Bibliographische Detailangaben
Veröffentlicht in:ChemInform 2016-07, Vol.47 (32), p.no-no
Hauptverfasser: O'Donnell, Michael, Charrier, Jean‐Damien
Format: Artikel
Sprache:eng
Schlagworte:
amination, N‐alkylation, N‐arylation
C‐C bond formation
pyrimidine derivatives
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Beschreibung
Zusammenfassung:2,4‐Substituted pyrimidines are prepared by C‐2 functionalization of 2‐chloro‐4‐tetrafluorophenoxypyrimidine (I) by cross‐coupling reactions followed by SNAr displacement at C‐4 position with a variety of amines.
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201632170