Stereoselective synthesis of tuberculostatic agent (S,S)-ethambutol

Stereoselective synthesis of tuberculostatic agent (S,S)-ethambutol

A simple and efficient asymmetric synthesis of (S,S)-Ethambutol has been carried out using a chiral butanediol. The synthesis was completed within six steps with an overall yield 53% and the enantiomeric purity of final product was 98%. All the reactions were very clean and the yields are excellent.

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Veröffentlicht in:Organic communications 2014-01, Vol.7 (1), p.28
Hauptverfasser: J Kranthi Kumar, Narsaiah, A Venkat
Format: Artikel
Sprache:eng
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Zusammenfassung:A simple and efficient asymmetric synthesis of (S,S)-Ethambutol has been carried out using a chiral butanediol. The synthesis was completed within six steps with an overall yield 53% and the enantiomeric purity of final product was 98%. All the reactions were very clean and the yields are excellent.
ISSN:1307-6175