Enantioselective Palladium-Catalyzed Oxidative [beta],[beta]-Fluoroarylation of [alpha],[beta]-Unsaturated Carbonyl Derivatives

Enantioselective Palladium-Catalyzed Oxidative [beta],[beta]-Fluoroarylation of [alpha],[beta]-Unsaturated Carbonyl Derivatives

The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective [beta]-fluorination of [alpha],...

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Veröffentlicht in:Angewandte Chemie International Edition 2016-07, Vol.55 (31), p.9045
Hauptverfasser: Miro, Javier, delPozo, Carlos, Toste, F Dean, Fustero, Santos
Format: Artikel
Sprache:eng
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Zusammenfassung:The site-selective palladium-catalyzed three-component coupling of deactivated alkenes, arylboronic acids, and N-fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step-economical approach to the stereoselective [beta]-fluorination of [alpha],[beta]-unsaturated systems.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201603046