Back Cover: Cytotoxic, Antiangiogenic and Antitelomerase Activity of Glucosyl- and Acyl- Resveratrol Prodrugs and Resveratrol Sulfate Metabolites (ChemBioChem 14/2016)

The back cover picture shows how resveratrol (RES) prodrugs deliver resveratrol to the cell and how, later, RES gets metabolized mainly to RES sulfates in MCF‐7, HT‐29 and HEK‐293 cells. We found that RES glucosylated prodrugs were more cytotoxic in HT‐29 and MCF‐7 cells than RES itself. Likewise, some RES sulfates showed similar or higher cytotoxicity than RES. We also observed that VEGF production was decreased by RES glucosylated compounds, and RES‐disulfate diminished it even more than RES. More information about the resveratrol prodrugs as anticancer drugs and the biological activity of RES sulfates can be found in the full paper by M. Carda, J. C. Morales et al. on page 1343 in Issue 14, 2016 (DOI: 10.1002/cbic.201600084).