Phosphine-Thiourea-Organocatalyzed Asymmetric C−N and C−S Bond Formation Reactions

Phosphine–thiourea based‐organocatalysts derived from l‐proline promoted C−N or C−S bond formation of tert‐butoxycarbonyloxy‐Morita—Baylis—Hillman adducts with phthalimide or alkyl thiols, respectively. Good yields and enantioselectivities up to 93 % were achieved. Phosphine–thiourea‐based organocatalysts derived from l‐proline efficiently promote C−N and C−S bond formation through the asymmetric allylic substitution of tert‐butoxycarbonyloxy‐Morita–Baylis–Hillman (MBH) adducts with phthalimide or alkyl thiols, respectively. The desired products are afforded in good yields and enantioselectivities.