Synthesis, characterization and antimicrobial activities of amide derivatives of febuxostat intermediate

Synthesis, characterization and antimicrobial activities of amide derivatives of febuxostat intermediate

A series of new carboxamide derivatives of 3-(4-(5-(ethoxycarbonyl)-4-methylthiazol-2-yl)phenoxy)propionic acid were synthesized by Schotten-Baumann reaction. The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. The target molecules were evaluated for their effic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Organic communications 2015-04, Vol.8 (2), p.43
Hauptverfasser: Badvel, Sreedhar, Veera Reddy Tummaluru, Venugopal Reddy Katta, Vidya Sagar Reddy Gandi, Naga Raju Chamarthi, Padmavathi Venkatapuram
Format: Artikel
Sprache:eng
Schlagworte:
Antimicrobial agents
Chemical compounds
Inhibitor drugs
Pharmaceutical sciences
Uric acid
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A series of new carboxamide derivatives of 3-(4-(5-(ethoxycarbonyl)-4-methylthiazol-2-yl)phenoxy)propionic acid were synthesized by Schotten-Baumann reaction. The newly synthesized compounds were characterized by IR, NMR and mass spectral analysis. The target molecules were evaluated for their efficacy as antimicrobial agents in vitro by disc diffusion method. Compounds 4c, 4f, 4g and 4i showed high inhibitory activity.
ISSN:1307-6175