2,5-Disubstituted 1,3,4-oxadiazole derivatives of chromeno[4,3-b]pyridine: synthesis and study of antimicrobial potency

2,5-Disubstituted 1,3,4-oxadiazole derivatives of chromeno[4,3-b]pyridine: synthesis and study of antimicrobial potency

A convenient synthesis of 1,3,4-oxadiazole containing derivatives of chromeno[4,3- ]pyridine ( , and ) starting from 4-hydroxycoumarin is presented. The synthesized compounds were screened for antimicrobial activity against representative bacterial and fungal species. The MIC (minimum inhibitory con...

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Veröffentlicht in:Heterocyclic communications 2016-06, Vol.22 (3), p.123-130
Hauptverfasser: Jadhav, Ghanshyam R., Deshmukh, Dattatray G., Medhane, Vijay J., Gaikwad, Vishwas B., Bholay, Avinash D.
Format: Artikel
Sprache:eng
Schlagworte:
1,3,4-oxadiazole
antimicrobial activity
Antimicrobial agents
Chemical synthesis
coumarin
multistep synthesis
pyridine
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Zusammenfassung:A convenient synthesis of 1,3,4-oxadiazole containing derivatives of chromeno[4,3- ]pyridine ( , and ) starting from 4-hydroxycoumarin is presented. The synthesized compounds were screened for antimicrobial activity against representative bacterial and fungal species. The MIC (minimum inhibitory concentration) of the synthesized compounds ranges between 5 and 15 μg/mL, which is comparable with MIC of standard drugs. Compounds , , and have the highest potency for certain bacteria and fungi.
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2015-0215