Is the question of phenobarbital as potential liver cancer risk factor for humans really resolved?

Is the question of phenobarbital as potential liver cancer risk factor for humans really resolved?

The mechanisms by which phenobarbital causes tumor promotion or inhibition are still not fully understood. Without such deeper mechanistic understanding, however, it will be difcult if not impossible to appropriately stratify the human population into individuals at risk or not at risk from a substa...

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Veröffentlicht in:Archives of toxicology 2016-06, Vol.90 (6), p.1525-1526
Hauptverfasser: Braeuning, Albert, Schwarz, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Carcinogens
Environmental Health
Guest Editorial
Humans
Liver
Liver Neoplasms
Occupational Medicine/Industrial Medicine
Pharmacology/Toxicology
Phenobarbital
Risk Factors
Toxicity
Tumorigenesis
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Zusammenfassung:The mechanisms by which phenobarbital causes tumor promotion or inhibition are still not fully understood. Without such deeper mechanistic understanding, however, it will be difcult if not impossible to appropriately stratify the human population into individuals at risk or not at risk from a substance like PB with tumor-selecting properties.
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-016-1712-0