Elucidating the specificity of non-heparin based conformational activators of antithrombin for factor Xa inhibition

Elucidating the specificity of non-heparin based conformational activators of antithrombin for factor Xa inhibition

A theoretical screening approach for identifying alternative non-heparin conformational activators of antithrombin for factor Xa inhibition is an ideal strategy to identify lead compounds and modify them for an appreciable activation of antithrombin.

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Veröffentlicht in:Journal of natural science, biology and medicine biology and medicine, 2011-12, Vol.2 (3), p.49-49
Hauptverfasser: Rashid, Qudsia, Azhar, Md Asim, Naseem, Asma, Khan, Md Sazzad, Singh, Poonam, Jairajpuri, Mohamad
Format: Artikel
Sprache:eng
Schlagworte:
Anticoagulants
Antithrombins
Binding sites
Conformation
Properties
Protein binding
Protein conformation
Proteins
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Zusammenfassung:A theoretical screening approach for identifying alternative non-heparin conformational activators of antithrombin for factor Xa inhibition is an ideal strategy to identify lead compounds and modify them for an appreciable activation of antithrombin.
ISSN:0976-9668
2229-7707