Signal-to-Noise Enhancement in Optical Detection of Single Viruses With Multispot Excitation

We present fluorescence detection of single H1N1 viruses with enhanced signal to noise ratio (SNR) achieved by multispot excitation in liquid-core antiresonant reflecting optical waveguides (ARROWs). Solid-core Y-splitting ARROW waveguides are fabricated orthogonal to the liquid-core section of the...

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Veröffentlicht in:	IEEE journal of selected topics in quantum electronics 2016-07, Vol.22 (4), p.6-11
Hauptverfasser:	Ozcelik, Damla, Stott, Matthew A., Parks, Joshua W., Black, Jennifer A., Wall, Thomas A., Hawkins, Aaron R., Schmidt, Holger
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiresonant reflecting optical waveguides (ARROWs) Biomedical optical imaging biophotonics Fluorescence integrated waveguides liquid core waveguides Liquid waveguides Optical device fabrication Optical signal processing Optical waveguides optofluidics Signal to noise ratio Y-splitters
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Beschreibung
Zusammenfassung:	We present fluorescence detection of single H1N1 viruses with enhanced signal to noise ratio (SNR) achieved by multispot excitation in liquid-core antiresonant reflecting optical waveguides (ARROWs). Solid-core Y-splitting ARROW waveguides are fabricated orthogonal to the liquid-core section of the chip, creating multiple excitation spots for the analyte. We derive expressions for the SNR increase after signal processing, and analyze its dependence on signal levels and spot number. Very good agreement between theoretical calculations and experimental results is found. SNR enhancements up to 5×10 4 are demonstrated.
ISSN:	1077-260X 1558-4542
DOI:	10.1109/JSTQE.2015.2503321