Isolation and Characterisation of Insulin-Releasing Compounds from Pseudechis australis and Pseudechis butleri Venom

Isolation and Characterisation of Insulin-Releasing Compounds from Pseudechis australis and Pseudechis butleri Venom

Crude venom from two elapid snakes Pseudechis australis and Pseudechis butleri was fractionated by gel filtration chromatography and selected fractions screened for in vitro insulin-releasing activity using clonal pancreatic BRIN-BD11 cells. Following acute 20-min incubation at 5.6 mM glucose, 9 fra...

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Veröffentlicht in:International journal of peptide research and therapeutics 2016-06, Vol.22 (2), p.211-218
Hauptverfasser: Moore, Sara W. M., Bhat, Vikas K., Flatt, Peter R., Gault, Victor A., McClean, Stephen
Format: Artikel
Sprache:eng
Schlagworte:
Animal Anatomy
Biochemistry
Biomedical and Life Sciences
Diabetes
Histology
Insulin
Life Sciences
Molecular Medicine
Morphology
Pharmaceutical Sciences/Technology
Pharmacology/Toxicology
Polymer Sciences
Snakes
Venom
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Zusammenfassung:Crude venom from two elapid snakes Pseudechis australis and Pseudechis butleri was fractionated by gel filtration chromatography and selected fractions screened for in vitro insulin-releasing activity using clonal pancreatic BRIN-BD11 cells. Following acute 20-min incubation at 5.6 mM glucose, 9 fractions exhibited significant (P 
ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-015-9499-z