T3 Acute Muscle Loss in the Critically Ill: From Bedside to Bench

T3 Acute Muscle Loss in the Critically Ill: From Bedside to Bench

Background Critical illness survivors demonstrate skeletal muscle wasting with associated functional impairment. We prospectively characterised this process, and defined the pathogenic roles of altered protein synthesis and degradation. Methods Critically ill patients (n=63, 59% male, age 54.7±18.0...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Thorax 2012-12, Vol.67 (Suppl 2), p.A1-A2
Hauptverfasser: Puthucheary, ZA, Rawal, J, Mcphail, M, Connolly, B, Ratnayake, G, Sidhu, PS, Seymour, J, Chan, P, Hopkins, P, Shrikrishna, D, Hopkinson, N, Polkey, MI, Velloso, C, Agley, CC, Selby, A, Limb, M, Edwards, L, Smith, K, Rennie, M, Rowlerson, A, Moxham, J, Harridge, SDR, Hart, N, Montgomery, H
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background Critical illness survivors demonstrate skeletal muscle wasting with associated functional impairment. We prospectively characterised this process, and defined the pathogenic roles of altered protein synthesis and degradation. Methods Critically ill patients (n=63, 59% male, age 54.7±18.0 years, APACHE II score 23.5±6.5) were recruited
ISSN:0040-6376
1468-3296
DOI:10.1136/thoraxjnl-2012-202678.003