PGC1[alpha] drives NAD biosynthesis linking oxidative metabolism to renal protection
PGC1[alpha] protects against kidney injury by upregulating enzymes that enhance nicotinamide adenine dinucleotide (NAD) and driving local accumulation of the fatty acid breakdown product [beta]-hydroxybutyrate, which leads to increased production of the renoprotective prostaglandin E.sub.2.
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| Veröffentlicht in: | Nature (London) 2016-03, Vol.531 (7595), p.528 |
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| container_title | Nature (London) |
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| creator | Tran, Mei T Zsengeller, Zsuzsanna K Berg, Anders H Khankin, Eliyahu V Bhasin, Manoj K Kim, Wondong Clish, Clary B |
| description | PGC1[alpha] protects against kidney injury by upregulating enzymes that enhance nicotinamide adenine dinucleotide (NAD) and driving local accumulation of the fatty acid breakdown product [beta]-hydroxybutyrate, which leads to increased production of the renoprotective prostaglandin E.sub.2. |
| doi_str_mv | 10.1038/nature17184 |
| format | Article |
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| source | Nature; Alma/SFX Local Collection |
| subjects | Accumulation Amino acids Biosynthesis Enzymes Gene expression Health aspects Kidneys Metabolism Metabolites Musculoskeletal system NAD (Coenzyme) Observations Renal function Rodents Solutes |
| title | PGC1[alpha] drives NAD biosynthesis linking oxidative metabolism to renal protection |
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