PGC1[alpha] drives NAD biosynthesis linking oxidative metabolism to renal protection

PGC1[alpha] drives NAD biosynthesis linking oxidative metabolism to renal protection

PGC1[alpha] protects against kidney injury by upregulating enzymes that enhance nicotinamide adenine dinucleotide (NAD) and driving local accumulation of the fatty acid breakdown product [beta]-hydroxybutyrate, which leads to increased production of the renoprotective prostaglandin E.sub.2.

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Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 2016-03, Vol.531 (7595), p.528
Hauptverfasser: Tran, Mei T, Zsengeller, Zsuzsanna K, Berg, Anders H, Khankin, Eliyahu V, Bhasin, Manoj K, Kim, Wondong, Clish, Clary B
Format: Artikel
Sprache:eng
Schlagworte:
Accumulation
Amino acids
Biosynthesis
Enzymes
Gene expression
Health aspects
Kidneys
Metabolism
Metabolites
Musculoskeletal system
NAD (Coenzyme)
Observations
Renal function
Rodents
Solutes
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Zusammenfassung:PGC1[alpha] protects against kidney injury by upregulating enzymes that enhance nicotinamide adenine dinucleotide (NAD) and driving local accumulation of the fatty acid breakdown product [beta]-hydroxybutyrate, which leads to increased production of the renoprotective prostaglandin E.sub.2.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature17184