Two cases of birth defects overlapping Stratton-Parker syndrome after multiple pesticide exposure

Sex Male Male Male Age at last examination 17 months 5 years 1 month 1 year 1 month Early developmental delay + + + Congenital heart defects + + - Pituitary gland hypoplasia NR + NR Wormian bones + NR NR Renal hypoplasia + NR NR Bowel defects Imperforate anus Imperforate anus Imperforate anus Genital abnormalities Bilateral cryptorchidism, hypospadias - Micropenis, hypospadias Brachycamptodactyly + NR NR Hypoplastic nose + + + +, present; -, absent; NR, not reported. The adverse effects of these pesticide cocktails are more than the sum of the effects of their separate constituents. [...]in our case we cannot exclude the role of a cocktail of endocrine disruptors at epigenetic, genetic or physiological levels during parental gametogenesis or pregnancy.