Evidence of differing genotypic effects of PPAR  in women and men

The differing findings of these studies could be related to differences in the characteristics of the participants. Since coronary artery disease is caused by interactions between multiple environmental and genetic factors, it is likely that the genetic backgrounds and the exposures to environmental risk factors, such as high fat diets, of the subjects with coronary artery disease of our study were different from those of the subjects of the other two studies mentioned above. 15, 16 These genetic and environmental factors might influence the genotypic effects of PPARα on adiposity. In a manner consistent with the different susceptibilities to coronary artery disease of the two genders, men and women differed in some characteristics such as age, percentage of smokers, and family history of coronary artery disease. [...]it is possible that men and women might be influenced by differing environmental and genetic factors.