Measurement of folate

Measurement of folate

Folic acid (pteroylmonoglutamic acid) is a provitamin and, as such, is itself inactive, but it is chemically reduced first to dihydrofolate and then to tetrahydrofolate in passage through the liver. 2 The first of these reductions is slow and may be overwhelmed; as a consequence, unreduced folic aci...

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Veröffentlicht in:Journal of clinical pathology 2012-04, Vol.65 (4), p.378-379
1. Verfasser: Leeming, Robert
Format: Artikel
Sprache:eng
Schlagworte:
Acids
cobalamin
diagnostic screening
Folate
Folic Acid - analysis
Humans
inherited pathology
Metabolic disorders
Tetrahydrofolates - analysis
Vitamin B
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Beschreibung
Zusammenfassung:Folic acid (pteroylmonoglutamic acid) is a provitamin and, as such, is itself inactive, but it is chemically reduced first to dihydrofolate and then to tetrahydrofolate in passage through the liver. 2 The first of these reductions is slow and may be overwhelmed; as a consequence, unreduced folic acid enters the circulatory system and then tissue and is polyglutamated, stored and may compete with 'natural' folates.
ISSN:0021-9746
1472-4146
DOI:10.1136/jclinpath-2011-200271