Paraoxonase-1 and oxidative status in common Mediterranean [beta]-thalassaemia mutations trait, and their relations to atherosclerosis

Paraoxonase-1 and oxidative status in common Mediterranean [beta]-thalassaemia mutations trait, and their relations to atherosclerosis

Aims Investigation of paraoxonase-1 (PON1) activity with oxidative status parameters and the increased susceptibility to atherogenesis in β-thalassaemia-trait (BTT) subjects. Methods Sixty BTT subjects and 20 age- and sex-matched healthy controls were enrolled in the study. Serum PON1, total antioxi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of clinical pathology 2011-05, Vol.64 (5), p.437
Hauptverfasser: Labib, Hany A, Etewa, Rasha Lotfi, Gaber, Osama A, Atfy, Maha, Mostafa, Tamer M, Barsoum, Ihab
Format: Artikel
Sprache:eng
Schlagworte:
Antioxidants
Atherosclerosis
Cardiovascular disease
Cellulose acetate
Cholesterol
Hematology
Lipids
Lipoproteins
Mutation
Oxidative stress
Studies
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aims Investigation of paraoxonase-1 (PON1) activity with oxidative status parameters and the increased susceptibility to atherogenesis in β-thalassaemia-trait (BTT) subjects. Methods Sixty BTT subjects and 20 age- and sex-matched healthy controls were enrolled in the study. Serum PON1, total antioxidant capacity (TAC), malondialdehyde (MDA) and carotid artery intima-media thickness (CIMT) were determined. Qualitative detection of β-thalassaemia mutations was carried out. Results Serum PON1 activity and TAC were significantly lower in BTT subjects than in controls (p
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2011.090209