Snippets in haematology

Gene expression profiling is a powerful tool that has validated the FAB and WHO classifications of acute myeloid leukaemia. [...]in low-grade disease, morphological changes may be subtle and cytogenetic abnormalities absent, rendering diagnosis difficult.\n This bortezomib-induced NF-κB activation was shown to be mediated via the canonical pathway. Interestingly, dasatinib also prevented platelet activation by serum from patients with heparin-induced thrombocytopenia in a dose-dependent manner, perhaps a different potential therapeutic use for the drug.