Phaeochromocytoma and thrombotic microangiopathy: favourable outcome despite advanced renal failure

An MRI scan of the abdomen was performed for diffuse abdominal pain and showed a 4 cm tumour in the left adrenal gland ( figure 1A ). [...]a working diagnosis of phaeochromocytoma with malignant hypertension and thrombotic microangiopathy was made, and immunosuppressive therapy was discontinued. Bec...

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Veröffentlicht in:Journal of clinical pathology 2010-08, Vol.63 (8), p.754-756
Hauptverfasser: Schweizer, Heiko, Boehm, Joachim, Winterer, Jan Thorsten, Wild, Damian, Neumann, Hartmut P H, Wiech, Thorsten, Stubanus, Mike, Kuehn, E Wolfgang
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container_end_page 756
container_issue 8
container_start_page 754
container_title Journal of clinical pathology
container_volume 63
creator Schweizer, Heiko
Boehm, Joachim
Winterer, Jan Thorsten
Wild, Damian
Neumann, Hartmut P H
Wiech, Thorsten
Stubanus, Mike
Kuehn, E Wolfgang
description An MRI scan of the abdomen was performed for diffuse abdominal pain and showed a 4 cm tumour in the left adrenal gland ( figure 1A ). [...]a working diagnosis of phaeochromocytoma with malignant hypertension and thrombotic microangiopathy was made, and immunosuppressive therapy was discontinued. Because of the clinical response to plasmaphaeresis, we think that phaeochromocytoma complicated by malignant hypertension coexisting with TTP is a likely diagnosis in this case.
doi_str_mv 10.1136/jcp.2010.077511
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[...]a working diagnosis of phaeochromocytoma with malignant hypertension and thrombotic microangiopathy was made, and immunosuppressive therapy was discontinued. Because of the clinical response to plasmaphaeresis, we think that phaeochromocytoma complicated by malignant hypertension coexisting with TTP is a likely diagnosis in this case.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.2010.077511</identifier><identifier>PMID: 20702482</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Abdomen ; Acute Kidney Injury - etiology ; Adrenal gland ; Adrenal Gland Neoplasms - complications ; Adrenals. Adrenal axis. Renin-angiotensin system (diseases) ; Adult ; arteries ; Biological and medical sciences ; Biopsy ; blood vessels ; Dehydrogenases ; Endocrinopathies ; Family medical history ; Female ; Gangrene ; Humans ; Hypertension ; Investigative techniques, diagnostic techniques (general aspects) ; kidney ; Magnetic Resonance Imaging ; Medical sciences ; nephrology ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pheochromocytoma - complications ; Plasma ; Prognosis ; Renal failure ; Thrombotic Microangiopathies - etiology ; Tumors ; Urine</subject><ispartof>Journal of clinical pathology, 2010-08, Vol.63 (8), p.754-756</ispartof><rights>2010, Published by the BMJ Publishing Group Limited. 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[...]a working diagnosis of phaeochromocytoma with malignant hypertension and thrombotic microangiopathy was made, and immunosuppressive therapy was discontinued. Because of the clinical response to plasmaphaeresis, we think that phaeochromocytoma complicated by malignant hypertension coexisting with TTP is a likely diagnosis in this case.</description><subject>Abdomen</subject><subject>Acute Kidney Injury - etiology</subject><subject>Adrenal gland</subject><subject>Adrenal Gland Neoplasms - complications</subject><subject>Adrenals. Adrenal axis. Renin-angiotensin system (diseases)</subject><subject>Adult</subject><subject>arteries</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>blood vessels</subject><subject>Dehydrogenases</subject><subject>Endocrinopathies</subject><subject>Family medical history</subject><subject>Female</subject><subject>Gangrene</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>kidney</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>nephrology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Adrenal axis. Renin-angiotensin system (diseases)</topic><topic>Adult</topic><topic>arteries</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>blood vessels</topic><topic>Dehydrogenases</topic><topic>Endocrinopathies</topic><topic>Family medical history</topic><topic>Female</topic><topic>Gangrene</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>kidney</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>nephrology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. 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[...]a working diagnosis of phaeochromocytoma with malignant hypertension and thrombotic microangiopathy was made, and immunosuppressive therapy was discontinued. Because of the clinical response to plasmaphaeresis, we think that phaeochromocytoma complicated by malignant hypertension coexisting with TTP is a likely diagnosis in this case.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>20702482</pmid><doi>10.1136/jcp.2010.077511</doi><tpages>3</tpages></addata></record>
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subjects Abdomen
Acute Kidney Injury - etiology
Adrenal gland
Adrenal Gland Neoplasms - complications
Adrenals. Adrenal axis. Renin-angiotensin system (diseases)
Adult
arteries
Biological and medical sciences
Biopsy
blood vessels
Dehydrogenases
Endocrinopathies
Family medical history
Female
Gangrene
Humans
Hypertension
Investigative techniques, diagnostic techniques (general aspects)
kidney
Magnetic Resonance Imaging
Medical sciences
nephrology
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pheochromocytoma - complications
Plasma
Prognosis
Renal failure
Thrombotic Microangiopathies - etiology
Tumors
Urine
title Phaeochromocytoma and thrombotic microangiopathy: favourable outcome despite advanced renal failure
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