041 Serial change in health related quality of life over 1 year following transcatheter aortic valve implantation: predictors of health outcomes

IntroductionSevere aortic stenosis (AS) reduces the length and quality of a patient's life. Transcatheter Aortic Valve Implantation (TAVI) is superior to standard medical therapy and non-inferior to Surgical Aortic Valve Replacement (SAVR) for 1-year mortality. HRQOL is an important outcome measure, for which there is limited evidence in TAVI populations. This study aimed to assess serial changes in patient health related quality of life (HRQOL) over time and identify predictors of patient benefit.Method102 (age 80±0.6 years, female 51%) attending for TAVI consented to participate. Two HRQOL questionnaires, the SF12v2 with physical and mental component summaries (PCS and MCS) and the EQ-5D (with Visual Analogue Scale; VAS) were completed at baseline, 30 days, 6 and 12 months. A SF-6D utility measure was calculated from the SF12 survey.ResultsHRQOL significantly improved over 12 months (PCS, p=0.002; EQ-5D, p=0.02; VAS, p=0.01; SF-6D p=0.048). The greatest change occurred from baseline to 30 days (p