LV diastolic function and filling pressure assessment using the time intervals changes on the mitral inflow and mitral annular velocities

Background The aim of our study was to evaluate left ventricular (LV) function using the time intervals between mitral inflow and mitral annular velocities. Methods 40 patients (mean age: 42 years) with heart failure and 30 age-matched controls (mean age: 41 years) were enrolled. Patients were classified into two groups according to the ratio of E/E': (1) group 1: E/E' from 8 to 15; (2) group 2: E/E'>15. The measurements were: the time intervals from the R-wave on the ECG to the peak E-wave and the onset of E-wave on the transmitral flow (TMF) (R-pE, R-onset E), to the peak E’-wave and onset of E’-wave on the LV septal wall of TDI (R-pE', R-onset E’); The time intervals from the onset of P-wave on the ECG to the peak A-wave and onset of A-wave on the TMF (P-pA, P-onset A), to the peak A’-wave and onset of A-wave on TDI (P-pA', P-onset A’). Results The time intervals were shown in table 1. The time intervals of P-pA' and P-onset A’ were significantly decreased in group 1 and group 2 compared to the control group respectively (121.1±13.0, 91.6±20.5 vs 157.2±16.3, p