The prognostic value of aetiology in patients with chronic systolic heart failure

Objective To determinate the prognostic value of aetiology in patients with chronic systolic heart failure (CSHF). Methods Data of in-hospital patients with CSHF were investigated between 2000 and 2010 from 12 hospitals in Hubei Province. Univariate and multivariate Cox proportional hazards analyses were used to explore the differences in the all-cause mortality, heart failure (HF) mortality and sudden cardiac death (SCD) among patients caused by different aetiologies. Univariate and multivariate Cox regression analyses were then used on selecting demographic and clinical variables predicting the all-cause mortality, HF mortality and SCD. The ROC curve were then developed to assess the incremental additive information from aetiology. Results (1) 16681 patients were enrolled of which male was 9887/59.27%. (2) All-cause mortality accounted 34.50%, 54.30%, 41.48% and 15.76%; HF mortality was 30.11%, 44.95%, 36.25% and 13.10% and SCD accounted 8.46%, 8.45%, 9.84% and 1.05% in patients with CHD, DCM, HHD and RHD, respectively. (3) Compared with patients with RHD, adjusted HRs for all-cause mortality were 1.554 (1.240 to 1.947; p