The short-term effects of pre-treatment of statins on reperfusion and short-term clinical prognosis after percutanous coronary intervention in patients with non-ST-segment elevation acute coronary syndrome

Objective To evaluate the effect of pre-treatment with statin on the reperfusion and short-term clinical prognosis in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) who underwent successful primary percutanous coronary intervention (PCI). Methods A total of 162 consecutive high-risk NSTE-ACS patients undergoing PCI received simvastatin for 3 days before PCI. The patients were randomly divided into two groups: standard statin group (20 mg simvastatin, n=81) and intensive statin group (80 mg simvastatin, n=81). The difference of TIMI and myocardial blush grade (MBG) of target arteries before and after PCI, serum level of CK-MB at 24 h, LVEFand the incidence of main adverse cardiac events (MACE) at 30-day follow-up were examined in the 2 groups. Results The percentage of TIMI grade 2–3 flow and MBG 2–3 perfusion were significantly higher in intensive statin group than that in standard statin group before PCI (p