FACTOR XA INHIBITION BY RIVAROXABAN ATTENUATES CARDIAC REMODELING DUE TO HYPOXIC STRESS VIA PAR-2/ERK/NF-[kappa]B SIGNALING PATHWAY

FACTOR XA INHIBITION BY RIVAROXABAN ATTENUATES CARDIAC REMODELING DUE TO HYPOXIC STRESS VIA PAR-2/ERK/NF-[kappa]B SIGNALING PATHWAY

Conclusions Rivaroxaban attenuates both atrial and ventricular remodeling induced by IH at least partly through its anti-inflammatory effect via PAR-2/ERK/κB signaling pathway, which might be a novel therapeutic strategy by Xa inhibition against cardiac remodeling in patients with AF.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of the American College of Cardiology 2016-04, Vol.67 (13), p.2238
Hauptverfasser: Azuma, Misa, Yoshimura, Fumi, Tanikawa, Shota, Hosako, Shogo, Kato, Ryuji, Ijiri, Yoshio, Izumi, Yasukatsu, Yoshiyama, Minoru, Hayashi, Tetsuya
Format: Artikel
Sprache:eng
Schlagworte:
Cardiology
Heart attacks
Hypoxia
Oxidative stress
Rodents
Sleep apnea
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Conclusions Rivaroxaban attenuates both atrial and ventricular remodeling induced by IH at least partly through its anti-inflammatory effect via PAR-2/ERK/κB signaling pathway, which might be a novel therapeutic strategy by Xa inhibition against cardiac remodeling in patients with AF.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(16)32239-2