Antenatal glucocorticoid treatment is not associated with long-term metabolic risks in individuals born before 32 weeks of gestation

Background:A single course of maternal glucocorticoid treatment is effective in reducing neonatal mortality after preterm birth. However, in animals, maternal glucocorticoid treatment is associated with lifelong hyperglycaemia and hypertension, and impaired nephrogenesis in offspring. Findings from...

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Veröffentlicht in:Archives of disease in childhood. Fetal and neonatal edition 2008-11, Vol.93 (6), p.F442-F447
Hauptverfasser: Finken, M J J, Keijzer-Veen, M G, Dekker, F W, Frölich, M, Walther, F J, Romijn, J A, van der Heijden, B J, Wit, J M
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Sprache:eng
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Zusammenfassung:Background:A single course of maternal glucocorticoid treatment is effective in reducing neonatal mortality after preterm birth. However, in animals, maternal glucocorticoid treatment is associated with lifelong hyperglycaemia and hypertension, and impaired nephrogenesis in offspring. Findings from studies in humans on this topic are highly contradictory due to a number of methodological flaws, and renal function after glucocorticoid exposure has never been assessed.Objectives:To assess in individuals born
ISSN:1359-2998
1468-2052
DOI:10.1136/adc.2007.128470