An unusual intracameral precipitation after trabeculectomy

[...]in the presence of corneal wounds, cefuroxime can diffuse and achieve high AC concentrations, even after topical application. 3 Vancomycin HCl 2 mg/ml has been reported to be physically compatible in vitro when mixed with cefuroxime sodium at a Y-site injection at concentrations 4 of 1, 10, 50...

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Veröffentlicht in:British journal of ophthalmology 2010-08, Vol.94 (8), p.1107-1107
Hauptverfasser: Raj, A, Feyi-Waboso, A, Pegler, S
Format: Artikel
Sprache:eng
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Zusammenfassung:[...]in the presence of corneal wounds, cefuroxime can diffuse and achieve high AC concentrations, even after topical application. 3 Vancomycin HCl 2 mg/ml has been reported to be physically compatible in vitro when mixed with cefuroxime sodium at a Y-site injection at concentrations 4 of 1, 10, 50 and 150 mg/ml. In a related publication, Raju et al 5 observed vancomycin's pH-dependent precipitation in vitro; they noticed visible precipitation of vancomycin in a balanced salt solution, which has a pH of 7.6.
ISSN:0007-1161
1468-2079
DOI:10.1136/bjo.2009.159780