SAT0022 Lack of Association between Serum 25-Hydroxyvitamin D Concentrations and Cervical Human Papillomavirus Infection in Systemic Lupus Erythematosus

Background Growing evidence demonstrates the role of vitamin D deficiency in infections. Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that has been linked to vitamin D insufficiency. Objectives We aimed to evaluate whether vitamin D deficiency is associated with cervical human papilloma virus (HPV) infection in women with SLE. Methods We conducted a cross-sectional, prospective, observational study in women with SLE (1997 ACR classification criteria). A structured questionnaire was administered to the study subjects to ascertain the possible behavioural and biologic risk factors associated with cervical HPV infection. The Systemic Lupus Erythematosus Disease Activity Index, validated for the Mexican population (mexSLEDAI) was used to assess disease activity. A gynaecological evaluation and cervical cytology screen were performed. HPV detection and genotyping were made by PCR and linear array assay. Plasma 25(OH) levels were quantified by enzyme immunoassay. Results A total of 67 SLE women were analysed. Mean age was 44.8±10.6 years and disease duration 42.5±11.8 years. Median serum vitamin D level was 18.9 ng/mL (p25: 15.2; p75: 23.1). The demographics were similar in patients with and without vitamin D insufficiency (