FRI0502 Osteoporosis and Fracture Risk in Outpatients with Systemic Sclerosis

Background Osteoporosis (OP) is a frequent complication of a number of chronic inflammatory diseases. Only Rheumatoid Arthritis (RA) is included in the FRAX algorythm to calculate fracture risk but also Systemic Sclerosis (SSc) displays many disease-specific OP risk factors (chronic inflammation, malnutrition, steroid use, etc.) Objectives To determine OP frequency and fracture risk by FRAX in outpatients with SSc Methods After consent, in outpatients with SSc (le Roy criteria) of a University Hospital, bone mineral density (BMD) was calculated by Dual Energy X-Ray Absorptiometry (DEXA) at the femoral neck and lumbar spine and FRAX was obtained by the calculation tool (http://www.shef.ac.uk/FRAX). A routine SSc evaluation (according to EUSTAR) was performed as well. Age- and BMI-matched early AR (ACR/EULAR 2010 criteria) patients and healthy controls (HC) were enrolled as well. Results Seventy-one SSc patients (3:68 M:F, age 66±9yrs, 57:14 limited:diffuse cutaneous, median disease duration 8.5, 2.4-14.7yrs, median disease activity 1, 0.25-2), 44 AR (11:33 M:F, age 62±12yrs, median DAS28 4.42, 3.94-5) and 29 healthy controls (all F, 60.1±10.7yrs) were enrolled. OP was detected in 42/71 (59%) SSc patients. Disease duration was significantly higher in SSc-OP patients (10.5, 4.3-16.6 vs 5.5, 1.6-9.8, p