AB1073 Analysis of survival and causes of death of patients with gout

Background Gout - an independent risk factor of overall mortality and mortality from cardiovascular disease, serum uric acid levels have almost no effect on the risk of mortality [1]. Objectives To analyze survival and causes of death in patients with gout. Methods The study included 305 patients with cristal-verified gout. Patients (pts)were observed in the Research Institute of Rheumatology from 2002 to 2011, 38 patients (12.5%) were not available. Mean age at the beginning of the observation was 51,5±11,4, the monitoring period was 6,1±1,4 years or 1629 person-years. The examination included assessment of the indicators anthropometry, biochemical analysis (lipid and carbohydrate metabolism, renal function, uric acid, hs-CRP), diagnosis of comorbid diseases and metabolic syndrome (MS) (ATP III criteria). Survival was calculated using the Kaplan-Meier method, the odds ratio of death for metabolic syndrome (MS) and its components, chronic kidney disease (CKD), ischemic heart disease (IHD), chronic heart failure (CHF). Results Survivalof ptswas 95%in 3 years, 93%in 5 years,85% in 7 years from the beginning of the observation. 34 pts died (12.7%). The causes of death in pts were cardiovascular complications (22 pts(65%)), cancer pathology (7 pts(20%)), renal failure (2 pts (6%)), accident (2 pts (6%)), infection (1 patient (3%)). The odds ratio (OR) of death in patients with gout from any cause and cardiovascular accidents, was highfor IHD, CHF, CKD,MS and some of its components (table). Table 1. Odds ratio (OR; 95% CI) of death in patients with gout from any cause and cardiovascular accidentsin the presence of MSand its components, IHD, CHF, CKD The estimated parameterOR of death from any causeOR of cardiovascular death (95% CI)(95% CI) 1) MS1.81 (0.81-4.06)1.69 (0.64-4.45) 2) Fasting glucose (≥110 mg/dl)2.38 (1.15-4.93)2.14 (0.89-5.16) 3) Abdominal obesity (waist circumference >102 cm - Male, >88 cm – Female)1.20 (0.56-2.58)0.98 (0.37-2.43) 4) HDL cholesterol (