AB1037 Bone mineral density reference database in algerian male population: Study in douera city

Background The diagnosis of osteoporosis is based on patients bone mineral density (BMD) values that are compared to reference values. Clinical studies that have compared BMD between populations showed that according to the reference curve used, the number of osteoporotic patients may vary and lead to an unnecessary treatment or inversely. It seemed us more appropriate to determine these values in a sample of an Algerian population. Few data are available about bone mineral density in normal men. Objectives to Determine the values of bone mineral density in healthy young men (aged from 21 to 39 years for the T-score), and to determine values of bone mineral density in healthy men (aged from 40 to 74years old for the Z-score). Methods It is a descriptive cross-sectional uni-centric study carried out in a randomly sampled population throughout 52 districts. A minimum of 30 subjects were included in each 5-years age group ranging from 20 to 74 years. Non-inclusion criteria: any situation suggesting the presence of osteoporosis, which can interfere with bone metabolism or with BMD measureament. Psychiatric illness and alcoholism. BMD was measured at the hip and spine using a Hologic Discovery 2000 densitometer (Hologic Inc., Waltham, MA). Statistical analysis was performed using SPSS version 8.0. Results three hundred and thirty one men (331) were included. Eleven (11) groups were obtained (5-Years age groups) and mean BMD values were calculated for each one. The BMD values at the total hip and total spine (sites most used in practice) are respectively (mean ± SD) 1.023±0.119 g/cm2 and 1.038±0.125 g/cm2. The average bone density at various sites of the hip and spine are maximum before age 40. Analysis of T-score at the hip and spine, shows that the incidence of osteoporosis was overestimated by 9.4% comparatively when using NHANES reference. The bone mineral loss is very low over the years and is not significant. Conclusions This study showed that BMD of our population is different from a normal range and this could lead to misclassify significant percentage of subjects and overestimate the prevalence of osteoporosis. This difference has already been proven in several populations. Experts strongly recommend the use of local references. Disclosure of Interest None Declared