AB0188 The serum levels of adipocytokines (leptin, adiponectin and resistin) in ankylosing spondylitis patients

Background There is evidence that adipocytokines play an important role in metabolism and in inflammation. Adipocytokines are involved in numerous rheumatic diseases, such as rheumatoid arthritis, osteoarthritis and systemic lupus erythematosus. They exert potent modulatory actions on target tissues and cells in rheumatic diseases, including cartilage, synovium and immune cells. Objectives The aim of our study is to determine the serum leptin, adiponectin and resistin levels in patients with ankylosing spondylitis (AS) and to investigate the relationship with disease activity markers. Methods Leptin, adiponectin and resistin serum levels were measured in 50 AS patients and in 20 matched healthy control using commercially available enzyme-linked immunosorbent assays. Leptin, adiponectin, and resistin levels were correlated with clinical parameters including erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Bath AS Disease Activity Index (BASDAI), Bath AS Disease Functional Index (BASFI), and Bath AS global score (BASG). Results AS patients exhibited significantly higher resistin [Mediun (interquartile range) 3.6 (2.3∼5.1) vs. 2.7 (1.9∼3.4) μg/ml, p=0.03], but no difference in leptin and adiponectin levels [31.9 (18.9-58.9) vs. 30.3 (11.9∼83.9) ng/ml; [28.5 (14.6∼51.4) vs. 24.5 (13.6∼48.5), respectively p=NS)]. No correlation was found between leptin, adiponectin, and erythrocyte sedimentation rate, c-reactive protein levels, or BASDAI, BASFI and BASG. The resistin level was correlated with BASDAI (r: 0.364; p=0.013). There are no changes in serum adipokine concentrations after 3 months TNF blocker treatment. Conclusions Serum level of resistin are increased in patients with AS and correlated with BASDAI. Further studies are needed to elucidate the role of adipocytokines in AS. Disclosure of Interest None Declared