AB0607 Effect of probiotic lactobacillus casei shirota on clinical manifestations and serum cytokines in patients with rheumatoid arthritis

Background Probiotics are live microorganisms administered primarily in fermented milk products that increase the viability of the microbiota, allow the physiological processes of the intestine and modulate the immune system.The probiotic L. casei Shirota has decreased the inflammatory response in mice with collagen-induced arthritis. Objectives To determine the effect of Lactobacillus casei Shirota on the clinical manifestations, gastrointestinal symptoms and serum levels of pro and anti-inflammatory cytokines: TNF-α, IL-1 b and IL-10 in patients with active RA. Methods We performed a controlled single blinded clinical trial that included 19 female patients with active RA (DAS >3.2), ≥18 years of age, with no other inflammatory rheumatic o infectious disease and on stable treatment (DMARDs and prednisone