THU0344 DAS-28, SDAI and CDAI in the patients with rheumatoid arthritis and concomitant fibromyalgia

Background Composite indices DAS-28 (Disease Activity Score, assessing 28 joints), SDAI (Simplified Disease Activity Index), CDAI (Clinical Disease Activity Index) are widely used instruments for the assessment of disease activity in the patients (pts) with rheumatoid arthritis (RA), but they may not be sufficient to evaluate activity in cases of RA associated with chronic pain syndromes such as fibromyalgia (FM). Objectives To examine the FM impact on disease activity composite indices in pts with RA. Methods We examined 120 pts (29 males, 91 females) with RA on the presence of concomitant FM according the ACR criteria (1990). All the patients were examined by the same rheumatologist, assessing TJC (tender joint count), SJC (swollen joint count) and TPC (tender point count). Laboratory parameters included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF) and anti-citrullinated peptide antibody (ACPA). RA activity was evaluated by three composite indices (DAS-28, SDAI and CDAI) and functional disability by Health Assessment Questionnaire (HAQ). Results The diagnosis of FM was established in 25 (20.8%) pts with RA (RAF), 4 men and 21 women. RA and RAF pts did not differ significantly in sociodemographic characteristics (age, eduacation, marital status, RA duration), laboratory inflammatory markes, RF and ACPA seropositivity. RAF pts in comparison to RA pts were found to reach significantly higher scores in all three composite indices (DA-28 5.35±1.1 vs. 3.67±1.4, p