SAT0551 Location Dependence of the Microstructure of Cartilage and of Subchondral Cortical and Trabecular Bone Microstructure in Knees with NO or Mild OA Assessed by High Resolution Micro-Computed Tomography

Background Loss of articular cartilage and alterations in subchondral bone architecture with the thickening of the cortical subchondral plate and trabeculae are important characteristics of osteoarthritis (OA). The local heterogeneity of these structures in knees with no or mild OA is unknown. Its quantification could help to better understand the changes induced in osteoarthritis. Objectives To determine whether in non OA knees the relationship among cartilage volume, subchondral plate volume and porosity and structural parameters of the subchondral trabecular bone are location dependent. Methods Twenty two left cadaveric knees, with no or mild medial femoro-tibial osteoarthritis (Kellgren-Lawrence grading scale