FRI0229 Henoch-schoenlein purpura nephritis and IGA nephropaty: A comparative clinical study

Background Henoch-Schonlein Purpura Nephritis (HSPN) and IgA Nephropathy (IgAN) have been traditionally considered related diseases Objectives To establish the possible differences and similarities between both entities. Methods Study of an unselected population of 141 patients with HSPN and 55 with IgAN from a teaching hospital. HSP was diagnosed according to the criteria proposed by Michel et al (J Rheumatol 1992). IgAN was diagnosed according to renal biopsy in 49 patients, in the remaining 6 cases biopsy was not performed due to typical clinical features. The statistical analysis was performed with the STATISTICA software (Statsoft Inc.). Continuous variables (normally and not normally distributed) were compared with the 2-tailed Student’s t-test or the Mann-Whitney U test, respectively. The chi-square test was used for the dichotomous variables. Results The mean age at onset was of 28.7±26.6 years (range; 2-84) in HSPN and 35.5±13.2 (range; 12-68) in IgAN (p=NS). Most patients in both conditions were male; 56.7% in HSPN and 63.6% in IgAN (p=NS). Precipitating events were found in 58 (41.2%) of patients with HSPN and 5 (27.3%) cases with IgAN (p= NS). The most frequent precipitating events in HSPN and IgAN were respectively drug intake (22% vs 22.5%; p NS) and an upper respiratory tract infection (34.5% vs 19.5%; p=NS). Extra-renal manifestations were more common in HSPN [skin (97.1% vs 18.6%; p