FRI0020 Presence of Synovial Lymphocyte Aggregates Predicts Clinical Response to DMARD Therapy in Patients with Early Rheumatoid Arthritis

Background Predicting prognosis in patients with early RA remains a challenge. There is currently limited data from early arthritis cohorts examining the relationship between synovial pathotype, clinical phenotype and clinical outcome, including tissue obtained from small joints biopsy. Objectives The aim of this study was to evaluate in an early RA cohort the association between baseline synovial pathotype -including synovial tissue from small joints- clinical phenotype and clinical response to DMARD therapy. Methods A cohort of 67 DMARD naïve patients with early (